HDGC Teleconference Seminar
نویسندگان
چکیده
Let me deal with the tone and approach issues first. I found it disappointing that the paper adopts a tone that I find somewhat arrogant and condescending. This tone is adopted throughout and is best exemplified by the concluding remarks on the last page. This impression is exacerbated by the sometimes slick use of linguistic pyrotechnics, also well exemplified in the last two pages, and particularly the last three sentences. The overall impression that I was left with, was someone to trying to demonstrate how much more clever they are than the plodding planners and the benighted bureaucrats who are involved in the Greater Limpopo Project. This is a personal response, but one that I increasingly have to a growing body of social science research.
منابع مشابه
Hereditary diffuse gastric cancer: a family diagnosis and treatment.
Hereditary diffuse gastric cancer (HDGC) is a rare cancer representing approximately 2% of all gastric cancers. It is caused by CDHI gene mutations, inherited in an autosomal dominant fashion, that affect the function of E-cadherin. Approximately 38% of HDGC families have a CDHI gene mutation. With an estimated 75% penetrance rate, carriers are at high risk for HDGC. We describe the case of a C...
متن کاملCatenin family genes are not commonly mutated in hereditary diffuse gastric cancer.
BACKGROUND Approximately one third of the hereditary diffuse gastric cancer (HDGC) families carry germline mutations in the E-cadherin gene (CDH1). Risk prediction in members of families with this rare but deadly cancer could be improved by the identification of additional HDGC genes in non-CDH1 families. METHODS Affected individuals from 22 CDH1 mutation-negative families were screened for g...
متن کاملE-Cadherin Destabilization Accounts for the Pathogenicity of Missense Mutations in Hereditary Diffuse Gastric Cancer
E-cadherin is critical for the maintenance of tissue architecture due to its role in cell-cell adhesion. E-cadherin mutations are the genetic cause of Hereditary Diffuse Gastric Cancer (HDGC) and missense mutations represent a clinical burden, due to the uncertainty of their pathogenic role. In vitro and in vivo, most mutations lead to loss-of-function, although the causal factor is unknown for...
متن کاملAllele-specific CDH1 downregulation and hereditary diffuse gastric cancer.
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer susceptibility syndrome characterized by early-onset diffuse gastric cancer (DGC) and lobular breast cancer. E-cadherin (CDH1) heterozygous germline mutations and deletions are found in 40% of families. Independent of CDH1 alterations, most HDGC tumours display mislocalized or absent E-cadherin immunoexpression, therefore ...
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Teleconferencing is an essential feature in any business telephone system. A teleconference allows associates to engage in a group discussion by conducting a virtual meeting while remaining at geographically dispersed locations. Teleconferencing increases productivity while reducing travel costs and saving travel time. In a VoIP telephone system, we face the significant challenge of providing a...
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تاریخ انتشار 2003